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Information for transplant units - ANZKX program

The ANZKX program is a collaborative trans-Tasman living donor kidney transplant program involving centres in Australia and New Zealand.

The primary goal of the program is to increase living donor kidney transplants by identifying matches for incompatible donor-recipient pairs. An additional goal of ANZKX is to improve immunological matching for compatible donor-recipient pairs. The ANZKX team can discuss options with transplant units prior to entry of compatible pairs to ensure the program matches needs.

From 2021, continuous matching is performed so units are encouraged to enrol pairs as soon as they are ready.

Please contact the ANZKX team to discuss any specific matching needs of your donor-recipient pairs.

Feedback can be given to transplant units on how to improve the probability of pairs being matched in the program.

Registering a patient in the program

Donor and recipient pairs are registered in the ANZKX online registry (MMEx) by transplant coordinators as outlined in the ANZKX protocol. Test results, patient consent and ministerial approval forms are also uploaded to this system.

When a pair is registered, the transplant unit can contact the ANZKX team for any specific matching needs.

Protocols and forms

When a pair is being registered in the ANZKX program, the unit should ensure compliance with the ANZKX protocol, including consent procedures as documented below.

If you have any queries about the following protocols and forms, please contact the ANZKX team directly.

Protocols

ANZKX pathways

Forms for download

Compatible pairs and ANZKX

A compatible pair may be considered suitable for participation in ANZKX, particularly if there is a high degree of HLA mismatch or poor eplet matching. Participation in ANZKX can particularly benefit younger patients, who may need another transplant in the future.

ANZKX does not match compatible pairs to improve age difference between donor and recipient.

For further information see the ANZKX compatible pair protocol (645KB PDF).

If you have any queries about a compatible pair, please contact the ANZKX team to discuss the options available.

Out of ANZKX protocol criteria donors

The ANZKX national protocol (1.41 MB PDF) has set criteria for participation.

Transplant units can discuss with the ANZKX medical team if they have any donors who do not meet the program’s criteria but they believe should still be accepted. If one of these donors is allowed to be enrolled, then these details will be provided to the recipient unit if they are matched.

Out of donor criteria patients should be counselled that they might be harder to match and hence wait longer in the program.

Resources for outpatient clinics

The characteristics of incompatible donor pairs differ and, in order to appropriately inform patients of their chances of being matched, the following resources may be useful.

Outcome data

  • The ANZKX program has facilitated over 400 kidney transplants since its inception in 2010 and now has approximately 50 transplants occurring each year.
  • On average, the number of registered pairs in the program at any time is between 60 and 90.
  • 57% of all recipients registered have received a transplant through the program.
  • The majority of matches are made in the first 6 to 12 months after a pair is entered. The matchability of donor and recipient will influence the waiting time for a match.
  • Patient and graft survival outcomes at one and 5 years when pursued through the ANZKX program are excellent and equivalent to transplant outcomes for live donor directed donation.

The ANZKX program aims for the time from match to transplant to be 4 to 8 weeks. In order to achieve this, transplant units should make a decision about an offer within 48 hours and ensure surgical teams’ agreement within 7 days. This requires surgical review of the CT renal angiogram and discussion between all surgeons involved.

Please see further information regarding the offers to transplant timeline here via the ANZKX offers to transplant pathway (PDF).

Since 2021 ANZKX has moved to continuous matching and no longer performs match runs. By performing continuous matching, the program aims to reduce the waiting time from match offer to transplant to approximately 60 days or less. Historically, with match runs the average waiting time was around 100 days.

Please see further information regarding the updated enrolment and registration process here via the ANZKX registration pathway (PDF).

The matchability of a pair is dependent on donor and recipient blood group and cPRA. In particular, if a recipient is blood group O with cPRA>97%, a transplant unit should consider discussing how to improve the match potential.

Please see contact details for the ANZKX team in both Australia and New Zealand below, or email ANZKX@mh.org.au.

Communiques